Recent reports indicate a concerning decline in routine childhood vaccination rates globally. Parental engagement with health information is critical in shaping vaccine acceptance amid rising skepticism and shifting sociopolitical dynamics. In this study, we investigated how Canadian parents engaged with…
BackgroundObstetric violence encompasses harmful practices and care dynamics during pregnancy, childbirth, and postpartum that undermine women’s dignity, autonomy, and rights, and is associated with structural, gender, and organisational factors in maternity care.ObjectivesTo explore how midwives understand, experience, and interpret obstetric…
IntroductionThe medical intensive care unit (ICU) can be a challenging place for patients to get adequate sleep. Poor sleep quality before ICU admission could have significant consequences for sleep during ICU admission and for critical illness recovery. The objective of…
ObjectivesVarious drainage methods have been used for unresectable malignant hilar biliary obstruction (MHBO). However, controlling cholangitis and obstructive jaundice is still challenging. We performed a phase I/II study of endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) as primary drainage for MHBO.MethodsThis prospective Phase…
Amyloidosis, characterized by the deposition of abnormal protein fibrils in organs, is classified as systemic or localized. Amyloid light chain (AL)-type localized amyloidosis is uncommon, particularly when confined to the gastrointestinal tract. Herein, we report a case of localized gastrointestinal…
ObjectivesUnderwater endoscopic mucosal resection (UEMR) is an established treatment for non-pedunculated colorectal lesions, but securing an adequate resection margin can be difficult in selected cases due to poor visualization or snare instability. To address these limitations, we used a step-up…
Intra-abdominal hemorrhage is an extremely rare complication of endoscopic retrograde cholangiopancreatography (ERCP). We report a case of intra-abdominal bleeding that occurred after ERCP for choledocholithiasis with cholangitis in a patient with a cascade stomach. A man in his 70s underwent…
ObjectivesSmall bowel capsule endoscopy (CE) produces lengthy videos that are time-consuming to review and susceptible to missed lesions. We evaluated whether an open-source, pretrained artificial intelligence (AI) model (SEE-AI) could improve diagnostic performance and interpretation efficiency compared with conventional reading.MethodsWe…
Background and aimsOral sulfate solutions (OSSs) are used for low-volume bowel preparation but have a distinctive bitter taste. This study evaluated the efficacy and tolerability of OSSs compared with polyethylene glycol plus ascorbate (PEG-ASC) and identified patient factors associated with…
BET inhibitors (BETi) have shown potential to augment tumor immunogenicity in melanoma. However, conflicting evidence exists regarding their precise mechanism of action, and their overall impact on melanoma immunogenicity and antitumoral T cell responses remains unclear. To address this, human…