Abstract Reviews

Coffee consumption patterns and sleep quality among Saudi Youth: A cross-sectional study.

To examine coffee consumption patterns and their associations with sleep quality indicators among Saudi youth, and to identify independent predictors of poor sleep outcomes using multivariate regression. A cross-sectional study was conducted among 1458 consenting Saudi youth (aged 16-30 years)…

Neoadjuvant immunochemotherapy and postoperative acute hypoxemic respiratory failure in thoracic surgery: a multicentre cohort study.

ObjectivesWhile immune checkpoint inhibitors (ICIs) continue to transform the neoadjuvant treatment, its association with postoperative acute hypoxemic respiratory failure (AHRF) remains unexplored. This study aims to assess the association between neoadjuvant immunochemotherapy (nICT) and postoperative AHRF risk following thoracic tumour…

Acute beetroot juice ingestion fails to improve sprint performance and neuromuscular function in trained male sprinters: a randomized, double-blind, placebo-controlled study.

IntroductionThe aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters.MethodsTwelve male sprinters (24.3 ± 4.8 years) participated in a randomized, double-blind, and placebo-controlled study with two experimental…

Indole-3-carboxaldehyde from <i>Limosilactobacillus reuteri</i> targets the DUSP1/ERK/NOX2/ROS axis to enhance the bactericidal activity of macrophages and protects against sepsis.

The gut microbiota plays a critical regulatory role in the pathogenesis of sepsis, yet the immunomodulatory mechanisms of Limosilactobacillus reuteri (L. reuteri) and its metabolites in sepsis remain to be fully elucidated. This study found that the abundance of intestinal…

A comprehensive analysis of the adverse drug events of metastatic and unresectable gastrointestinal stromal tumor treatment options: avapritinib, imatinib, regorafenib, ripretinib, and sunitinib safety insights and implications.

BackgroundTreatments for metastatic, unresectable, or treatment-resistant gastrointestinal stromal tumors (GIST) include avapritinib, imatinib, regorafenib, ripretinib, and sunitinib. The FDA Adverse Event Reporting System (FAERS) database collects medication-related adverse events (AEs).Design and methodsReports in the FAERS database from each medication’s FDA…

How to co-create context-sensitive analyses of health service experiences: proposed guidelines for contextualist collaborative thematic analyses with co-researchers.

PurposeUser involvement is a prominent requirement in health services research across international health service contexts. However, current limitations with user-involved analytical approaches restrict researchers‘ sensitization to service users‘ contexts in analysis, with detrimental consequences for rigor and validity. In this…

Antibiotic-associated <i>Enterococcus</i> expansion in the gastrointestinal tract precedes infected necrosis in acute necrotizing pancreatitis.

Infected pancreatic necrosis complicates 30% of necrotizing pancreatitis cases, with intestinal bacterial translocation as the presumed mechanism. To characterize gastrointestinal microbiota dynamics preceding infection, we performed a predefined subgroup analysis of the POEMA cohort, a prospective multicenter microbiota study across…

Reshaping immunotherapy sequencing strategy: equivalent survival with induction plus consolidation vs. consolidation-only strategy in unresectable stage III NSCLC.

ObjectiveTo compare the efficacy and safety of a sequential combination of chemoradiotherapy (CRT) with immune checkpoint inhibitors (ICIs) administered as induction plus consolidation versus consolidation-only in patients with unresectable stage III non-small cell lung cancer (NSCLC).MethodsThis retrospective study enrolled 265…

Disparities in hospice enrollment timing and end-of-life care intensity across non-cancer diagnoses: a 10-year hospital-based cohort study.

IntroductionNon-cancer patients with advanced illnesses often experience delayed hospice referral and high-intensity care near the end of life, yet cross-diagnosis comparisons remain limited. This study examined diagnosis-specific patterns in hospice use and care intensity among non-cancer decedents.Materials and methodsWe conducted…

Shoulder-to-shoulder: healthcare professionals‘ experiences of learning during electronic health record implementation in municipal primary care.

BackgroundFormal training is commonly used in electronic health record (EHR) implementation, but often fails to address healthcare professionals‘ ongoing, context-specific learning needs. There is limited knowledge of how learning unfolds in practice when such training is experienced as insufficient, particularly…