PurposesCurrent methods for detecting monoclonal (M) proteins, such as immunofixation electrophoresis (IFE), serum protein electrophoresis (SPEP) and serum free light chains (sFLC), are limited by insufficient sensitivity and suboptimal efficiency. This study evaluated the performance and supplementary value of matrix-assisted…
BackgroundTo assess the short-term effectiveness of repeated low-level red light (RLRL) therapy in relieving asthenopia and enhancing accommodation in presbyopia.MethodsThis randomized, parallel-group, double-masked clinical trial enrolled adults with presbyopia and self-reported asthenopia. Participants were allocated using computer-generated randomization and randomly…
Perceived social support – feeling cared for and having access to a reliable network – has been linked to reduced stress and burnout, and greater quality of life among medical students. Yet, how perceived support systems evolve throughout medical school…
Although clinical trials have shown that nirsevimab is safe, post-licensure safety data from routine clinical settings are lacking. This study describes parent-reported health events occurring within seven days of nirsevimab administration. Post-licensure, active, safety surveillance was conducted during the 2024-25…
Coadministration of respiratory syncytial virus (RSV) and seasonal influenza vaccines can increase vaccination uptake. mRNA-1345 (mRESVIA, Moderna, Inc.) is indicated in multiple countries for prevention of RSV-lower respiratory tract disease in adults. This randomized, observer-blind, phase 3 study evaluated safety,…
ObjectivesSepsis is a life-threatening condition driven by a dysregulated immune response to infection, yet therapeutic options beyond antibiotics and vasopressors remain limited. Neutrophil extracellular traps (NETs) contribute significantly to sepsis-induced tissue injury, and NETosis inhibition has emerged as a potential…
BackgroundSexual harassment is a serious public health problem, yet there is a lack of clarity on its measurement.ObjectiveWe set out to develop a measurement tool to capture sexual harassment in the different spheres of women’s everyday lives.MethodsWe conducted 60 cognitive…
BackgroundImproving our understanding of the symptom-level relationships among posttraumatic stress disorder (PTSD), complex posttraumatic stress disorder (CPTSD), and posttraumatic growth (PTG) holds promise for identifying opportunities for effective interventions.ObjectiveWe sought to better understand the network of relationships among symptoms of…
This study evaluated the long-term outcomes of interventional therapy for transplant renal artery stenosis (TRAS). A total of 30 TRAS patients who underwent interventional treatment between February 2017 and September 2020 were included. Graft and recipient survival rates were assessed…
Hyperglycemia is a major risk factor for chronic kidney disease (CKD). This multicenter prospective study developed and validated a machine learning (ML) model to predict CKD risk in prediabetic and diabetic populations for early intervention, following TRIPOD+AI guidelines. Participants were…