BackgroundSodium-glucose cotransporter 2 inhibitors (SGLT2i) are increasingly prescribed because of their renal and cardiovascular benefits. However, polypharmacy is common among patients with chronic kidney disease (CKD), raising concerns about cumulative nephrotoxic medication exposure. This study aimed to evaluate drug-related problems…
ObjectivesTo investigate the relationship between frailty and diabetic kidney disease (DKD)-related renal complications using Mendelian randomization (MR) and complementary clinical analysis.MethodsTwo-sample MR was performed using genome-wide association study summary statistics to assess the association between genetically predicted frailty and type…
Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with increased mortality. Amino acids may improve renal perfusion, but their effect in patients undergoing aortic surgery remains unclear. We used the Aortic Surgery Database of…
Nephronophthisis (NPH), a rare but serious ciliopathy, is the predominant genetic cause of end-stage kidney disease (ESKD) in children and adolescents. Renal tubular dilatation and cyst formation are key pathological features of NPH. The mechanisms underlying renal cystogenesis remain poorly…
BackgroundPerforated necrotizing enterocolitis (PNEC) is a lethal complication in preterm infants with high mortality, but timely identification and prognostic stratification remain clinically challenging.MethodsThis retrospective cohort study analyzed 110 preterm infants with surgical NEC admitted between 2023-2025, stratified into non-intestinal perforation…
PurposePostoperative nausea and vomiting (PONV) is a common complication following thyroid surgery, often exacerbated by opioid use. Oliceridine, a novel G protein-biased μ-opioid receptor agonist, may reduce opioid-related adverse events. This study aimed to compare the impact of oliceridine versus…
BackgroundPain perception is a major limitation of office hysteroscopy and may lead to premature suspension of the procedure. Current guidelines do not routinely recommend local analgesia, and the effectiveness of paracervical block during office hysteroscopy performed with a vaginoscopic approach…
To combat antimicrobial resistance (AMR), a novel series of pyrrolo[3,2-f]quinazoline-diamine (PQD) derivatives (5a-5z) featuring a flexible benzyl-oxo-benzyl side chain were designed and synthesised via structural optimisation of lead compound IRS-16. All compounds exhibited potent dihydrofolate reductase (DHFR) inhibition. Compound 5a…
ObjectiveGel immersion endoscopic mucosal resection (GIEMR) has recently emerged as a novel technique for superficial non-ampullary duodenal epithelial tumors (SNADETs). However, its clinical advantages over underwater EMR (UEMR) remain unclear. This study compared the short- and long-term outcomes of GIEMR…
ObjectiveCystic fibrosis (CF) is a chronic disease that requires intensive daily self-management. Adherence can be challenging for adolescents and young adults (AYA) with CF. This manuscript reports on the characteristics, participation, and satisfaction outcomes of „tele-coaches“ who virtually delivered an…