ObjectivesPersistent measles transmission in fragile and conflict-affected settings is often linked to failure to complete multi-dose childhood immunization schedules. This study aimed to examine immunization completion and measles vaccine dropout to assess continuity of routine immunization services among children aged…
BackgroundOpen-access intensive care unit policies prioritize family integration. However, these guidelines may not fully account for the physical and psychological demands placed on surrogate decision-makers. Continuous, unregulated family presence is associated with physical exhaustion and cognitive fatigue. This burden may…
BackgroundHealthcare systems face increasing complexity alongside persistent nursing shortages. Shared Governance, operationalized through Unit Practice Councils, is a professional practice model designed to strengthen nurse engagement, accountability and evidence‑informed decision-making at the point of care. While Shared Governance has been…
ObjectiveTo evaluate the disease-modifying potential of SM03, a novel humanized anti-CD22 monoclonal antibody, for B cell-mediated autoimmune diseases by investigating its mechanism for suppressing B cell dysregulation in autoimmune milieu.MethodsSM03’s mechanism was assessed in-vitro using functional assays on stimulated human…
In January 2024, an outbreak of Crimean-Congo hemorrhagic fever (CCHF) was confirmed in Buyanja village, Lyantonde District, Uganda. Initially suspected to be anthrax, laboratory tests at the Uganda Virus Research Institute (UVRI) confirmed CCHF, prompting a One Health response. Five…
IntroductionLung injury is a frequent complication following heart failure (HF) due to systemic inflammation, hypoxia, and reduced cardiac function. This study compared the therapeutic effects of menstrual blood-derived stromal cells (MenSCs) and bone marrow-derived stromal cells (BMSCs) on HF-induced lung…
PurposeDespite the implementation of ongoing mass drug administration (MDA) campaigns, South Sudan remains endemic for six Preventive Chemotherapy Neglected Tropical Diseases (PC-NTDs); this persistent endemicity is attributed to complex sociocultural barriers and healthcare delivery challenges. Integrating gender equity and social…
BackgroundHigh-flow nasal cannula (HFNC) is standard therapy for acute hypoxaemic respiratory failure and is increasingly used in hypercapnic COPD. Comparative data between the asymmetrical and conventional HFNC interfaces regarding respiratory muscle work of breathing is limited. This study aimed to…
ObjectivesWhite globe appearance (WGA) is a small white lesion with a globular shape identified during magnifying endoscopy with narrow-band imaging. However, the association between WGA and metachronous gastric cancer remains unclear.MethodsThis study involved patients who underwent endoscopic submucosal dissection (ESD)…
ObjectivesEndoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using lumen-apposing metal stents (LAMS) is a treatment option for acute cholecystitis in high-risk surgical patients. However, data on extremely elderly and frail patients are limited. We report our initial experience with EUS-GBD using electrocautery-enhanced…