BackgroundAllergic rhinitis is a chronic non-communicable disease that adversely affects respiratory health and quality of life. Ginger-based formulations, owing to their anti-inflammatory and immunomodulatory properties, may offer a promising alternative therapeutic option.ObjectiveTo systematically review and meta-analyze evidence from animal studies…
Disturbances in the gut microbiome are increasingly correlated with neurodegenerative disorders, including Alzheimer’s disease. Multiple lines of emerging evidence are consistent with the microbiome’s involvement in disease pathology in AD by triggering or potentiating systemic and neuroinflammation, thereby influencing disease…
Orthohantaviruses are largely rodent-borne pathogens that can cause haemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. In Uganda, the risk of human exposure is heightened by known rodent hosts, close human-rodent interaction in rural areas, and poor housing conditions.…
Mechanical ventilation is a well-recognized risk factor for acute kidney injury (AKI), but the specific role of mean airway pressure (Pmean) remains insufficiently defined. We conducted a multicenter retrospective cohort study including 17,428 mechanically ventilated patients from the MIMIC-IV and…
Background: A conversation between a victim and a perpetrator of sexual abuse has the potential to reduce posttraumatic stress disorder (PTSD) symptoms in the victim. However, an actual conversation may not always be possible or feasible. Deepfake technology may offer…
Regional variation in the human gastrointestinal microbiome remains difficult to characterize because existing sampling methods either rely on invasive endoscopy or stool, which poorly reflects the upper gut. We evaluated a minimally invasive capsule-string device capable of collecting luminal and…
This study aimed to develop machine learning models to predict postoperative acute kidney injury (AKI) in surgical patients with pre-existing chronic kidney disease (CKD), a serious complication associated with high morbidity and accelerated disease progression. Using data from 3,851 surgical…
BackgroundAdvanced glycation end products (AGEs) link chronic hyperglycaemia to diabetic tissue damage. Serum AGE concentrations across the metabolic disease spectrum, from prediabetes through complicated diabetes, remain incompletely characterized, including the contribution of isolated dyslipidaemia.ObjectiveTo quantify serum AGEs across metabolic states…
Diabetic nephropathy (DN) is a major cause of chronic kidney disease, and sensitive biomarkers of early tubular injury remain limited. Fibrinogen-like protein 2 (FGL2) has been implicated in inflammation and fibrosis, but its clinical significance and mechanistic role in DN…
The risk of fractures and osteoporosis is higher in patients on hemodialysis than in the general population. We examined the association between computed tomography (CT)-measured trabecular attenuation at the first lumbar vertebra (L1 CT-attenuation), bone mineral density (BMD), and osteoporosis…