BackgroundHypertriglyceridemic acute pancreatitis (HTG-AP) is associated with a high risk of recurrence. This study aimed to identify risk factors for HTG-AP recurrence and to develop a predictive model integrating metabolic and clinical indicators.MethodsWe retrospectively enrolled patients with HTG-AP treated at…
We conducted a retrospective study using data from Zhejiang Province’s pertussis surveillance system between February 1 and May 1, 2024, defining school-based clusters as ≥5 cases occurring within 21 d in the same class. We identified 124 outbreaks involving 825 confirmed…
This retrospective study evaluated hematological, inflammatory, and nutritional indicators of peritonitis in 132 peritoneal dialysis (PD) patients, including 83 with confirmed peritonitis and 49 without peritonitis. The peritonitis group had a higher platelet-to-albumin ratio (PAR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio…
Anti-citrullinated protein autoantibodies promote inflammation and joint tissue injury and define a poor prognostic group of patients with rheumatoid arthritis (RA). Citrullinated autoantigens that drive this autoimmune response are generated by peptidylarginine deiminase (PAD) enzymes, which are predominately expressed and…
BackgroundRising female reproductive system malignant tumours and gonadotoxic treatments increase infertility risks in reproductive-age women, many of whom lack sufficient fertility preservation (FP) information.ObjectiveTo review advances, status, challenges and ethical/legal aspects of assisted reproductive technology (ART) for FP in these…
Natural killer (NK) cells play a key role in the standard treatment of diffuse large B-cell lymphoma (DLBCL). However, NK cells in DLBCL patients frequently display an exhausted phenotype, which is associated with poor clinical outcomes. The metabolic mechanisms contributing…
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by autoimmune-mediated destruction of intrahepatic bile ducts. Emerging evidence suggests that circular RNAs (circRNAs) play regulatory roles in autoimmune diseases, but their involvement in PBC remains unclear. This study…
BackgroundFemoral neck fractures in the elderly present significant challenges due to the complexity of the fractures and the fragility of patients. Traditional hollow screw internal fixation (HSIF) necessitates precise screw placement, which can be difficult due to compromised bone quality.…
Since the Covid-19 pandemic entered its endemic phase, France, Italy, and Hungary, as well as many other European countries, have observed a rise in vaccine hesitancy. This study employs a mixed-methods approach to understand the reasons behind this trend by…
Pneumococcal disease remains a major global cause of morbidity and mortality, yet vaccine uptake varies. Understanding how demographic, socioeconomic, and regional factors shape pneumococcal vaccine perceptions is essential for developing effective public health strategies. We conducted a stratified, cross-sectional survey…