BackgroundTo investigate the impact of area socioeconomic deprivation on the risk of major adverse kidney events (MAKEs) within 90 days post-discharge among patients with acute kidney injury (AKI).MethodsThis retrospective cohort study included patients with AKI between January 1, 2014, and December…
ObjectiveTo explore how Artificial intelligence (AI) scribes influence Norwegian general practitioners‘ (GPs) clinical practice, focusing on their impact on workflow, consultation routines, and professional responsibility, and to explore GPs reflections on AI technology and its alignment with their needs, expectations…
BackgroundSpindle cell tumors with RET rearrangements exhibit variable clinical behaviors, ranging from benign to highly aggressive malignancies. The underlying heterogeneity is suspected to be associated with distinct fusion partner genes. Understanding the impact of these fusion partners on oncogenic potential…
BackgroundIndoxyl sulfate (IS), a protein-bound uremic toxin derived from tryptophan metabolism, accumulates in patients with chronic kidney disease (CKD) and contributes to renal, vascular, and systemic injury. Conventional detection using LC-MS/MS is accurate but resource-intensive. To simplify IS quantification, Leadgene…
This retrospective study analyzed 10,934 hyperkalemia episodes to compare outcomes between the hyperkalemia routine group and the hyperkalemia standardized group, the latter managed with a strategy supported by the ‚Serum Potassium Management Center System‘ in a real-world implementation setting. The…
The Dual Prevention Pill (DPP) is a daily oral pill containing oral pre-exposure prophylaxis (PrEP) for protection against HIV and a combined oral contraceptive (COC) for the prevention of unintended pregnancy, currently under development. However, little is known about healthcare…
BackgroundMajor Depressive Disorder (MDD) has emerged as a leading cause of disability worldwide, affecting over 264 million people. Recent evidence reveals that disruption of circadian rhythms may be fundamental to MDD pathophysiology, opening new avenues for therapeutic intervention.MethodsThis review synthesizes…
Seasonal influenza and SARS-CoV-2 continue to contribute substantially to global morbidity and mortality. mRNA-1083 is an investigational multicomponent mRNA vaccine targeting seasonal influenza and SARS-CoV-2. In this phase 3, observer-blind, active-controlled trial (NCT06097273), adults (aged ≥50 y) were randomly assigned (1:1) to…
Polyethylene glycol-23 glyceryl distearate (GDS-23)-a noisome-forming diacylglycerol-polyethylene glycol-based nonionic surfactant-functions as a nanocarrier for drug delivery systems (DDS) and an enhancer of endogenous antioxidant capacity through nuclear factor erythroid 2-related factor 2 (Nrf2) activation. Here, we evaluated the potential of…
Vascular access dysfunction is a major cause of morbidity among maintenance hemodialysis (HD) patients. Calcium channel blockers (CCBs) may affect vascular remodeling; however, their impact on arteriovenous fistula (AVF) flow rate remains uncertain. We evaluated the association between antihypertensive therapy,…