Dipeptidyl peptidase 3 (DPP3), an aminopeptidase that degrades several key cardiovascular mediators, may induce and exacerbate hemodynamic instability during cardiogenic shock. Procizumab (PCZ) is a first-in-class humanized monoclonal antibody that inhibits DPP3 activity. In preclinical shock models, PCZ increased angiotensin…
African swine fever virus (ASFV) infection leads to severe lung lesions in the host, yet detailed insights into the in vivo immune response of the lung microenvironment to ASFV infection at the single-cell level remain limited. Here, we mapped the…
BackgroundEquipping future clinicians to recognize and reverse opioid overdoses requires experiential training and access to naloxone. Near-peer instruction may leverage cognitive and social congruence to enhance learning compared with traditional faculty-led models. This study evaluated whether near-peer teaching yields superior…
IntroductionThrombotic microangiopathy (TMA) is a common pathological phenotype of immunoglobulin A nephropathy (IgAN). Low-density granulocytes (LDGs) exhibit potent pro-inflammatory properties and promote neutrophil extracellular trap (NET) formation, playing a pivotal role in thrombus development. This study aims to investigate the…
Ebolaviruses, including EBOV, SUDV, and BDBV, cause severe hemorrhagic fever, yet currently licensed monoclonal antibody (mAb) therapies against EBOV lack cross-species efficacy. While mAbs offer high specificity, favourable safety profiles, and durable serum persistence, their susceptibility to viral escape highlights…
BackgroundPatients with nontuberculous mycobacterial (NTM) diseases associated with anti-interferon gamma autoantibodies (anti-IFN-γ auto-Abs) often experience recurrences, despite prolonged treatment, which requires intravenous anti-mycobacterial therapy. Linezolid (LZD) shows a potential as an adjunct treatment, but there is limited data on its…
BackgroundFirefighting tasks performed in full protective equipment (PPE) impose extreme thermal and physical strain, providing a model of high-intensity exercise with substantial fluid and electrolyte loss. This study compared the effects of plain water (W), a carbohydrate-electrolyte solution (CES), and…
Background: The 7 October 2023, terrorist attacks and the ensuing war led to widespread trauma exposure across Israel. This unprecedented event created a mass collective trauma, impacting millions through direct stressors like rocket fire and indirect exposure via graphic media.…
To examine coffee consumption patterns and their associations with sleep quality indicators among Saudi youth, and to identify independent predictors of poor sleep outcomes using multivariate regression. A cross-sectional study was conducted among 1458 consenting Saudi youth (aged 16-30 years)…
ObjectivesWhile immune checkpoint inhibitors (ICIs) continue to transform the neoadjuvant treatment, its association with postoperative acute hypoxemic respiratory failure (AHRF) remains unexplored. This study aims to assess the association between neoadjuvant immunochemotherapy (nICT) and postoperative AHRF risk following thoracic tumour…