IntroductionThe aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters.MethodsTwelve male sprinters (24.3 ± 4.8 years) participated in a randomized, double-blind, and placebo-controlled study with two experimental…
The gut microbiota plays a critical regulatory role in the pathogenesis of sepsis, yet the immunomodulatory mechanisms of Limosilactobacillus reuteri (L. reuteri) and its metabolites in sepsis remain to be fully elucidated. This study found that the abundance of intestinal…
BackgroundTreatments for metastatic, unresectable, or treatment-resistant gastrointestinal stromal tumors (GIST) include avapritinib, imatinib, regorafenib, ripretinib, and sunitinib. The FDA Adverse Event Reporting System (FAERS) database collects medication-related adverse events (AEs).Design and methodsReports in the FAERS database from each medication’s FDA…
PurposeUser involvement is a prominent requirement in health services research across international health service contexts. However, current limitations with user-involved analytical approaches restrict researchers‘ sensitization to service users‘ contexts in analysis, with detrimental consequences for rigor and validity. In this…
Infected pancreatic necrosis complicates 30% of necrotizing pancreatitis cases, with intestinal bacterial translocation as the presumed mechanism. To characterize gastrointestinal microbiota dynamics preceding infection, we performed a predefined subgroup analysis of the POEMA cohort, a prospective multicenter microbiota study across…
ObjectiveTo compare the efficacy and safety of a sequential combination of chemoradiotherapy (CRT) with immune checkpoint inhibitors (ICIs) administered as induction plus consolidation versus consolidation-only in patients with unresectable stage III non-small cell lung cancer (NSCLC).MethodsThis retrospective study enrolled 265…
IntroductionNon-cancer patients with advanced illnesses often experience delayed hospice referral and high-intensity care near the end of life, yet cross-diagnosis comparisons remain limited. This study examined diagnosis-specific patterns in hospice use and care intensity among non-cancer decedents.Materials and methodsWe conducted…
BackgroundFormal training is commonly used in electronic health record (EHR) implementation, but often fails to address healthcare professionals‘ ongoing, context-specific learning needs. There is limited knowledge of how learning unfolds in practice when such training is experienced as insufficient, particularly…
PurposesCurrent methods for detecting monoclonal (M) proteins, such as immunofixation electrophoresis (IFE), serum protein electrophoresis (SPEP) and serum free light chains (sFLC), are limited by insufficient sensitivity and suboptimal efficiency. This study evaluated the performance and supplementary value of matrix-assisted…
BackgroundTo assess the short-term effectiveness of repeated low-level red light (RLRL) therapy in relieving asthenopia and enhancing accommodation in presbyopia.MethodsThis randomized, parallel-group, double-masked clinical trial enrolled adults with presbyopia and self-reported asthenopia. Participants were allocated using computer-generated randomization and randomly…