BackgroundNigeria continues to experience high maternal and child mortality, despite extensive health reforms and international investment. Missed opportunities across the continuum of care, antenatal care (ANC), skilled birth attendance, facility-based delivery, and child immunization, contribute to these outcomes. Children who…
BackgroundWhile the American University of Beirut (AUB)-HAS2 cardiovascular risk index has emerged as a novel tool for preoperative risk stratification, its performance specifically in coronary artery disease (CAD) patients warrants further validation. This study aimed to evaluate the performance of…
IntroductionIndigenous peoples tend to differ from their non-Indigenous counterparts in use of health care services. Lack of available services, socioeconomic disparities, communication barriers and lack of trust have been found to be barriers driving the observed differences.AimThe aim of this…
BackgroundZ-hypnotics are commonly prescribed for insomnia, but their use in older adults is associated with an increased risk of adverse events.AimWe examined the long-term effect of brief intervention (BI) for inappropriate z-hypnotic use, where the control group crossed over to…
AimsEndometrial cancer (EC) is the most common gynecologic malignancy. Identifying prognostic biomarkers can improve outcome prediction and risk stratification.Patients and methodsThis study evaluated the prognostic value of serum human epididymis protein 4 (HE4) levels and matrix metalloproteinase (MMP)9/MMP13 gene polymorphisms…
BackgroundCurrent pharmacological treatments offer only limited benefits in altering the course of Alzheimer’s disease (AD). Given these limitations, nonpharmacological interventions have emerged as potential therapeutic strategies. This study investigates the therapeutic effects of 40 Hz light stimulation in AD and analyzes…
BackgroundTwin pregnancies carry perinatal risks. Gestational weight gain (GWG) is modifiable, but Institute of Medicine (IOM) twin recommendations may not suit Chinese women.MethodA retrospective cohort study included 3109 twin pregnancies delivered at Northwest Women’s and Children’s Hospital in Xi’an, China,…
BackgroundClonal hematopoiesis of indeterminate potential (CHIP)-associated somatic mutations are associated with increased cardiovascular and cerebrovascular risk in the general population; whether mutations detected at myeloid neoplasm (MN) diagnosis predict incident cardiovascular and cerebrovascular events (CCVEs) is unclear.MethodsWe retrospectively studied 203…
ObjectiveThis study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis.MethodsWe performed multi-omics analysis of TCGA and GEO datasets and validated the findings using clinical samples. The CRISPR/Cas9-mediated knockout and…
Studying the willingness to accept a new vaccine helps better understand the consumer behavior to formulate strategies to improve its acceptance when rolled out on a large scale. An online survey using a quota sampling covering all Malaysian states and…